prikaz prve stranice dokumenta Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres
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Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres
Acta Pharmaceutica, 69 (2019), 4; 635-648. https://doi.org/10.2478/acph-2019-0049
Duvnjak Romić, Marieta; Sušac, Anja; Lovrić, Jasmina; Cetina-Čižmek, Biserka; Filipović-Grčić, Jelena; Hafner, Anita

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Duvnjak Romić, M., Sušac, A., Lovrić, J., Cetina Čižmek, B., Filipović Grčić, J. i Hafner, A. (2019). Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres. Acta Pharmaceutica, 69. (4), 635-648. doi: 10.2478/acph-2019-0049

Duvnjak Romić, Marieta, et al. "Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres." Acta Pharmaceutica, vol. 69, br. 4, 2019, str. 635-648. https://doi.org/10.2478/acph-2019-0049

Duvnjak Romić, Marieta, Anja Sušac, Jasmina Lovrić, Biserka Cetina Čižmek, Jelena Filipović Grčić i Anita Hafner. "Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres." Acta Pharmaceutica 69, br. 4 (2019): 635-648. https://doi.org/10.2478/acph-2019-0049

Duvnjak Romić, M., et al. (2019) 'Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres', Acta Pharmaceutica, 69(4), str. 635-648. doi: 10.2478/acph-2019-0049

Duvnjak Romić M, Sušac A, Lovrić J, Cetina Čižmek B, Filipović Grčić J, Hafner A. Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres. Acta Pharmaceutica [Internet]. 2019. [pristupljeno 04.10.2024.];69(4):635-648. doi: 10.2478/acph-2019-0049

M. Duvnjak Romić, A. Sušac, J. Lovrić, B. Cetina Čižmek, J. Filipović Grčić i A. Hafner, "Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres", Acta Pharmaceutica, vol. 69, br. 4, str. 635-648, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:578073. [Citirano: 04.10.2024.]

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Naslov (engleski)Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres
AutorMarieta Duvnjak Romić
AutorAnja Sušac
AutorJasmina Lovrić
AutorBiserka Cetina-Čižmek
AutorJelena Filipović-Grčić
AutorAnita Hafner
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za farmaceutsku tehnologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
Sažetak (engleski)
The aim of this study was to evaluate long-term stability and assess the wound healing potential of the innovative melatonin-loaded lipid-enriched hybrid system compared to conventional melatonin-loaded chitosan microspheres. The hybrid system contained nanostructured lipid carrier incorporated in the chitosan matrix, in order to modify melatonin release and alter physicochemical characteristics of the delivery system. Stability testing was performed during a six-month period under two conditions - refrigerated (5±3 °C) and at room temperature (25 ± 2 °C/60 ± 5 % RH). Samples stored at both conditions were analyzed in terms of particle size, zeta potential, moisture content and thermal properties. At the end of testing, drug content was determined in all samples. Dressings wound healing potential was assessed by in vitro scratch test using human skin fibroblast cell line. Although both systems showed good stability characteristics, the addition of lipids in the system has improved its wound healing potential.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Pharmaceutica
Brojčani podacivol. 69, br. 4, str. 635-648
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2019-0049
URN:NBNurn:nbn:hr:163:578073
Datum objave publikacije2019
URL dokumentahttps://hrcak.srce.hr/225427
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-04-07 15:00:13