Učinkovitost hidrolizata kolagena u prevenciji i usporavanju starenja kože

professional thesis

• Author: Marija Gudelj Plazanić
• Mentor: Dubravka Vitali Čepo (mentor)
• Committee member: Donatella Verbanac (predsjednik povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Committee member: Ivana Čepelak (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of food chemistry); Zagreb
• Defense date and country: 2022-09-22, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja.
Brojne znanstvene studije pokazuju da suplementacija pojedinim nutrijentima ima potencijalnu ulogu u modulaciji starenja kože, među njima i kolagen, odnosno njegovi hidrolizati. Glavni cilj predloženog specijalističkog rada je iznjeti sustavni pregled dostupnih kliničkih istraživanja o učincima oralne suplementacije hidroliziranim kolagenom u svrhu poboljšanja znakova starenja kože. Dodatni ciljevi rada su dati cjelovit prikaz osobina i svojstava hidroliziranog kolagena te dostupnih istraživanja o mehanizmima njegovog djelovanja i biodostupnosti.
Metode.
Za izradu ovog teorijskog rada korišteni su znanstveni i stručni radovi dostupni putem baze PubMed.
Rezultati.
Istraživanja pokazuju da per os primjena hidroliziranog kolagena poboljšava kliničke manifestacije zdravlja kože, kroz djelovanje na različite aspekte građe i funkcije kože. Kao rezultat pregleda dostupne literature nameće se zaključak da nisu u potpunosti istraženi mehanizmi djelovanja hidroliziranog kolagena u koži, kao i važnost formulacije kolagena u pripravku.
Zaključak.
Potrebna su i daljna istraživanja kojima bi se definirale smjernice za doziranje i duljinu trajanja primjene hidroliziranog kolagena u svrhu postizanja optimalnog učinka.

Abstract (english)

Objectives.
Numerous studies show that supplementing certain nutrients, including collagen and its hydrolysates, can play a significant role in modulating the process of skin ageing. The main goal of this study was to conduct a systematic review of available clinical research on the anti-age effects of oral supplementation with hydrolyzed collagen Additional goals were to provide a comprehensive overview of the features and characteristics of available hydrolyzed collagen formulations and highlight the current knowledge of its mechanism of action and oral bioavailability.
Methods.
Scientific and professional papers available through the PubMed database were used to prepare this theoretical paper.
Results.
Research shows that per os application of hydrolyzed collagen improves clinical manifestations of skin health, by affecting various aspects of skin structure or function. However, mechanism of the action of hydrolyzed collagen in the skin have not been completely elucidated and neither was the importance of particular collagen formulations in products available in the market.
Conclusions.
Additional research is needed to define guidelines for the optimal dosage and duration of hydrolyzed collagen administration in order to achieve an clinically significant anti-age effect.

• Keywords: koža; starenje kože; kolagen; hidrolizirani kolagen
• Keywords (english): skin; skin aging; collagen; hydrolyzed collagen
• Language: croatian
• URN:NBN: urn:nbn:hr:163:640723
• Study programme: Title: Dermopharmacy and cosmetology; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije (sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-09-27 12:57:06