prikaz prve stranice dokumenta Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease
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Scientific paper - Original scientific paper
Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease
Croatica Chemica Acta, 81 (2008), 1; 73-80. urn:nbn:hr:163:381263
Rumora, Lada; Milevoj, Lara; Popović-Grle, Sanja; Barišić, Karmela; Žanić Grubišić, Tihana; Čepelak, Ivana

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Rumora, L., Milevoj, L., Popović Grle, S., Barišić, K., Žanić Grubišić, T. & Čepelak, I. (2008). Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease. Croatica Chemica Acta, 81. (1), 73-80. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:381263

Rumora, Lada, et al. "Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease." Croatica Chemica Acta, vol. 81, no. 1, 2008, pp. 73-80. https://urn.nsk.hr/urn:nbn:hr:163:381263

Rumora, Lada, Lara Milevoj, Sanja Popović Grle, Karmela Barišić, Tihana Žanić Grubišić and Ivana Čepelak. "Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease." Croatica Chemica Acta 81, no. 1 (2008): 73-80. https://urn.nsk.hr/urn:nbn:hr:163:381263

Rumora, L., et al. (2008) 'Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease', Croatica Chemica Acta, 81(1), pp. 73-80. Available at: https://urn.nsk.hr/urn:nbn:hr:163:381263 (Accessed 16 November 2024)

Rumora L, Milevoj L, Popović Grle S, Barišić K, Žanić Grubišić T, Čepelak I. Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease. Croatica Chemica Acta [Internet]. 2008 April 15 [cited 2024 November 16];81(1):73-80. Available at: https://urn.nsk.hr/urn:nbn:hr:163:381263

L. Rumora, L. Milevoj, S. Popović Grle, K. Barišić, T. Žanić Grubišić and I. Čepelak, "Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease", Croatica Chemica Acta, vol. 81, no. 1, pp. 73-80, April 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:381263. [Accessed: 16 November 2024]

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Metadata
Title (english)Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease
AuthorLada Rumora
AuthorLara Milevoj
AuthorSanja Popović-Grle
AuthorKarmela Barišić
AuthorTihana Žanić Grubišić
AuthorIvana Čepelak
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medical biochemistry and haematology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract (english)
Chronic obstructive pulmonary disease (COPD) is characterized by chronic local and systemic inflammation, and increased oxidative stress. Changes in peripheral blood leukocyte counts or in the fractions of leukocyte subsets might be implicated in the development of this disease. In this study, increased monocyte fraction was observed in COPD non-smokers. In light COPD smokers, the fraction of neutrophils was significantly increased along with significantly decreased lymphocyte fraction and lung function parameters. Heat shock proteins (Hsps) could stimulate antioxidant defence of cells by decreasing intracellular levels of reactive oxygen particles (ROS) and by neutralizing toxic effects of oxidized proteins. This study showed that the expression of Hsps in leukocytes was influenced by health and smoking status. Hsp70 and Hsp27 were significantly decreased in COPD ex-smokers and healthy smokers, but the most striking suppression in Hsps expression was detected in COPD smokers. It is suggested that this decline in Hsps intracellular levels could be implicated in the pathogenesis of COPD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 81, no. 1, pp. 73-80
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:381263
Publication2008-04-15
Document URLhttps://hrcak.srce.hr/23395
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-05-11 11:37:58