prikaz prve stranice dokumenta Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease
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Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease
Croatica Chemica Acta, 81 (2008), 1; 73-80. urn:nbn:hr:163:381263
Rumora, Lada; Milevoj, Lara; Popović-Grle, Sanja; Barišić, Karmela; Žanić Grubišić, Tihana; Čepelak, Ivana

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Rumora, L., Milevoj, L., Popović Grle, S., Barišić, K., Žanić Grubišić, T. i Čepelak, I. (2008). Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease. Croatica Chemica Acta, 81. (1), 73-80. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:163:381263

Rumora, Lada, et al. "Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease." Croatica Chemica Acta, vol. 81, br. 1, 2008, str. 73-80. https://urn.nsk.hr/urn:nbn:hr:163:381263

Rumora, Lada, Lara Milevoj, Sanja Popović Grle, Karmela Barišić, Tihana Žanić Grubišić i Ivana Čepelak. "Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease." Croatica Chemica Acta 81, br. 1 (2008): 73-80. https://urn.nsk.hr/urn:nbn:hr:163:381263

Rumora, L., et al. (2008) 'Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease', Croatica Chemica Acta, 81(1), str. 73-80. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:163:381263 (Datum pristupa: 02.10.2024.)

Rumora L, Milevoj L, Popović Grle S, Barišić K, Žanić Grubišić T, Čepelak I. Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease. Croatica Chemica Acta [Internet]. 15.04.2008. [pristupljeno 02.10.2024.];81(1):73-80. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:381263

L. Rumora, L. Milevoj, S. Popović Grle, K. Barišić, T. Žanić Grubišić i I. Čepelak, "Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease", Croatica Chemica Acta, vol. 81, br. 1, str. 73-80, Travanj 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:381263. [Citirano: 02.10.2024.]

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Naslov (engleski)Reduction in peripheral blood leukocyte heat shock proteins 27 and 70 expression in chronic obstructive pulmonary disease
AutorLada Rumora
AutorLara Milevoj
AutorSanja Popović-Grle
AutorKarmela Barišić
AutorTihana Žanić Grubišić
AutorIvana Čepelak
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za medicinsku biokemiju i hematologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Medicinska biokemija
Sažetak (engleski)
Chronic obstructive pulmonary disease (COPD) is characterized by chronic local and systemic inflammation, and increased oxidative stress. Changes in peripheral blood leukocyte counts or in the fractions of leukocyte subsets might be implicated in the development of this disease. In this study, increased monocyte fraction was observed in COPD non-smokers. In light COPD smokers, the fraction of neutrophils was significantly increased along with significantly decreased lymphocyte fraction and lung function parameters. Heat shock proteins (Hsps) could stimulate antioxidant defence of cells by decreasing intracellular levels of reactive oxygen particles (ROS) and by neutralizing toxic effects of oxidized proteins. This study showed that the expression of Hsps in leukocytes was influenced by health and smoking status. Hsp70 and Hsp27 were significantly decreased in COPD ex-smokers and healthy smokers, but the most striking suppression in Hsps expression was detected in COPD smokers. It is suggested that this decline in Hsps intracellular levels could be implicated in the pathogenesis of COPD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatica Chemica Acta
Brojčani podacivol. 81, br. 1, str. 73-80
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:381263
Datum objave publikacije2008-04-15
URL dokumentahttps://hrcak.srce.hr/23395
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-05-11 11:37:58