prikaz prve stranice dokumenta Capillary electrophoresis determination of pravastatin and separation of its degradation products
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Capillary electrophoresis determination of pravastatin and separation of its degradation products
Croatica Chemica Acta, 81 (2008), 4; 615-622. urn:nbn:hr:163:647858
Nigović, Biljana; Vegar, Ivana

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Nigović, B. i Vegar, I. (2008). Capillary electrophoresis determination of pravastatin and separation of its degradation products. Croatica Chemica Acta, 81. (4), 615-622. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:163:647858

Nigović, Biljana i Ivana Vegar. "Capillary electrophoresis determination of pravastatin and separation of its degradation products." Croatica Chemica Acta, vol. 81, br. 4, 2008, str. 615-622. https://urn.nsk.hr/urn:nbn:hr:163:647858

Nigović, Biljana i Ivana Vegar. "Capillary electrophoresis determination of pravastatin and separation of its degradation products." Croatica Chemica Acta 81, br. 4 (2008): 615-622. https://urn.nsk.hr/urn:nbn:hr:163:647858

Nigović, B. i Vegar, I. (2008) 'Capillary electrophoresis determination of pravastatin and separation of its degradation products', Croatica Chemica Acta, 81(4), str. 615-622. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:163:647858 (Datum pristupa: 10.10.2024.)

Nigović B, Vegar I. Capillary electrophoresis determination of pravastatin and separation of its degradation products. Croatica Chemica Acta [Internet]. 2008. [pristupljeno 10.10.2024.];81(4):615-622. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:647858

B. Nigović i I. Vegar, "Capillary electrophoresis determination of pravastatin and separation of its degradation products", Croatica Chemica Acta, vol. 81, br. 4, str. 615-622, 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:647858. [Citirano: 10.10.2024.]

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Podaci o radu
Naslov (engleski)Capillary electrophoresis determination of pravastatin and separation of its degradation products
AutorBiljana Nigović
AutorIvana Vegar
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za analitiku i kontrolu lijekova)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
Sažetak (engleski)
A capillary zone electrophoresis method for pravastatin determination was developed and validated. Rapid migration of negatively charged pravastatin molecule was obtained in alkaline buffer by the application of electric field of 30 kV. Influence of the pH value and ionic strength of running buffer, applied voltage and capillary temperature on mobility and sensitivity was evaluated. Detection wavelength was set to 237 nm. The method was applied to the determination of the drug in pharmaceutical dosage form. Pravastatin is a δ-hydroxy acid, which is prone to lactonize and epimerize in a pH-dependent manner. Micellar electrokinetic chromatographic approach was chosen to develop a method able to separate pravastatin and its degradation products in acidic media. The proposed method allows baseline separation of hydroxy acid and neutral lactone forms of the drug that appear as interconversion products depending on the pH value.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatica Chemica Acta
Brojčani podacivol. 81, br. 4, str. 615-622
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:647858
Datum objave publikacije2008
URL dokumentahttps://hrcak.srce.hr/31187
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-04-21 15:55:19