Posljednja karika u biotransformaciji acetilsalicilne kiseline: Nove spoznaje o metabolizmu

Stručni rad - Stručni rad

• Autor: Mirza Bojić
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku kemiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

The history of salicylates began four millennia ago. Salicylates were used for
centuries in the form of a herba drug - willow bark. Isolation of salicin started in
1829, followed by the first synthesis in 1857. lt took four decades to find the acetylated
form of salicylic acid that could be obtained as a pure substance. Aspirin was born
in 1897.
Salicylates were unique drugs in many ways. The first clinical trial was conducted
in 1763 and confirmed the antipyretic activity of willow bark. In 1899, clinical
trials confirmed the beneficial effects of aspirin, granting aspirin the status of a panacea
(universal remedy).
Owing to its analgesic, antipyretic, anti-inflammatory and antithrombotic properties,
aspirin is one of the most widely used drugs today. Every fifth adult takes
aspirin on a daily basis, and every second person aged 65 and above. The metabolism
of aspirin is revisited in this paper, highlighting the latest achievements in researching
its metabolic fare. Hydrolysis, glucuronidation and glycine conjugation, as major
metabolic reactions, are covered accompanied with the minor metabolic pathway of
aromatic hydroxylation. Addition of human cytochromes P450 completes the biotransformation
schemc of (acetyl)salicylic acid.

• Ključne riječi (hrvatski): acetilsalicilna kiselina; metabolizam; aromatska hidroksilacija; salicilurna kiselina
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Stručni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 71, br. 10, str. 529-535
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:132347
• Datum objave publikacije: 2015
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2020-10-01 15:43:18