Vitamin C i maligne bolesti

Stručni rad - Pregledni rad

• Autor: Zrinka Rajić
• Autor: Ivana Perković
• Autor: Ines Batinić-Haberle
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku kemiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Ascorbic acid, the infamous antioxidant and cofactor of many enzymes, is present in
the cell in millimolar, while in plasma and extracellular fluid in micromolar concentrations,
as monovalent ascorbate anion. The highest levels of ascorbate are found in the
brain, adrenal glands, white blood cells and skeletal muscles. Ascorbate is transported
into the cell via two sodium-dependent transporters - SVCTl and SVCT2 or as
dehydroascorbic acid via glucose transporters of the GLUT family.
Almost 40 years have passed since the first cancer cinical trials with vitamin C, which
showed that patients with ascorbate treatment benefited with enhanced quality and prolongation
of life. Further studies led to controversy since they have not corroborated these
findings and medical community concluded that vitamin C has no place in the cancer
therapy. Finally, evidences from the human physiology, which showed that only intravenously,
and not orally, administered ascorbate could be used as anticancer drug, gave
new prospective for the role of vitamin C in the cancer treatment.

• Ključne riječi (hrvatski): vitamin C; L-askorbinska kiselina
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 67, br. 5, str. 303-310
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:408734
• Datum objave publikacije: 2011
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2020-10-07 12:22:42