Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery

Znanstveni rad - Izvorni znanstveni rad

• Autor: Jasminka Peršec
• Autor: Andrej Šribar
• Autor: Monika Ilić
• Autor: Ivan Mamić
• Autor: Domagoj Kifer
• Autor: Ana-Marija Domijan
• Autor: Željan Maleš
• Autor: Petra Turčić
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za biofiziku)
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku botaniku)
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmakologiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

The aim of this study was to compare the effects of dexmedetomidine and dexamethasone as adjuvants to pre-operative epidural administration of local anesthetic (ropivacaine) in thoracic surgery on the post-operative level of pain, use of analgesics, inflammation, and oxidative stress. The study enrolled 42 patients who underwent elective thoracic surgery in a one-year period at the University Hospital Dubrava (Zagreb, Croatia). Based on a computer-generated randomization list the patients were assigned to the dexmedetomidine (n = 18) or dexamethasone (n = 24) group. Post-operatively, patients of dexmedetomidine group reported lower pain (VAS value 1 h post-surgery, 3.4 ± 2.7 vs. 5.4 ± 1.8, dexmedetomidine vs. dexamethasone, p < 0.01) and had lower analgesic requirements in comparison with dexamethasone group. Thus, dexmedetomidine in comparison with dexamethasone was more efficient in lowering pain and analgesia requirements 24 h after the surgery. On the contrary, dexamethasone had better anti-inflammatory properties (CRP level 24 h post-surgery, 131.9 ± 90.7 vs. 26.0 ± 55.2 mg L–1, dexmedetomidine vs. dexamethasone, p < 0.01). Both dexmedetomidine and dexamethasone exhibited antioxidant effects, however, their antioxidant properties should be further explored. The results of this study improve current knowledge of pain control in thoracic surgery.

• Ključne riječi (engleski): dexmedetomidine; dexamethasone; thoracotomy; local anesthetic; analgesic efficacy
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - međunarodna recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Acta Pharmaceutica
• Brojčani podaci: vol. 73, br. 4 (Special Issue), str. 691-707
• p-ISSN: 1330-0075
• e-ISSN: 1846-9558
• DOI: https://doi.org/10.2478/acph-2023-0040
• URN:NBN: urn:nbn:hr:163:589050
• Datum objave publikacije: 2023
• URL dokumenta: https://hrcak.srce.hr/308543
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-01-26 12:20:37