prikaz prve stranice dokumenta Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment
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Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment
Croatica Chemica Acta, 81 (2008), 1; 139-146. urn:nbn:hr:163:459799
Šegvić Klarić, Maja; Pepeljnjak, Stjepan; Rozgaj, Ružica

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Šegvić Klarić, M., Pepeljnjak, S. i Rozgaj, R. (2008). Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment. Croatica Chemica Acta, 81. (1), 139-146. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:163:459799

Šegvić Klarić, Maja, et al. "Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment." Croatica Chemica Acta, vol. 81, br. 1, 2008, str. 139-146. https://urn.nsk.hr/urn:nbn:hr:163:459799

Šegvić Klarić, Maja, Stjepan Pepeljnjak i Ružica Rozgaj. "Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment." Croatica Chemica Acta 81, br. 1 (2008): 139-146. https://urn.nsk.hr/urn:nbn:hr:163:459799

Šegvić Klarić, M., Pepeljnjak, S. i Rozgaj, R. (2008) 'Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment', Croatica Chemica Acta, 81(1), str. 139-146. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:163:459799 (Datum pristupa: 10.10.2024.)

Šegvić Klarić M, Pepeljnjak S, Rozgaj R. Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment. Croatica Chemica Acta [Internet]. 15.04.2008. [pristupljeno 10.10.2024.];81(1):139-146. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:459799

M. Šegvić Klarić, S. Pepeljnjak i R. Rozgaj, "Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment", Croatica Chemica Acta, vol. 81, br. 1, str. 139-146, Travanj 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:459799. [Citirano: 10.10.2024.]

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Podaci o radu
Naslov (engleski)Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment
AutorMaja Šegvić Klarić
AutorStjepan Pepeljnjak
AutorRužica Rozgaj
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za mikrobiologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
Sažetak (engleski)
After 24- and 48-hour treatment with 0.05, 0.5 and 5 mg/mL of fumonisin (FB1), beauvericin (BEA) and ochratoxin A (OTA) alone or combinations of two or all three mycotoxins in equal concentrations, Giemsa-stained binucleated PK15 cells were scored for the presence of micronuclei (MN), nuclear buds (NBs) and nucleoplasmic bridges (NPBs). Single mycotoxins induced MN and NPBs in a dose-dependent manner, showing predominantly clastogenic effect. OTA showed stronger genotoxic potential than FB1 and BEA, since 0.05 and 0.5 mg/mL OTA increased the frequency of MN and NPBs, respectively. Mycotoxin combinations increased the frequency of MN and NPBs, mostly in additive manner. A dose-dependent increase in NBs was observed after 24-hour exposure to single mycotoxins. Prolonged treatment with 5 mg/mL of each toxin alone as well as combined exposure to all mycotoxin concentrations resulted in a decrease in NBs, which could be related to the extrusion of micronuclei and/or saturation of the genotoxic effect. This is the first report on genotoxicity of BEA.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatica Chemica Acta
Brojčani podacivol. 81, br. 1, str. 139-146
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:459799
Datum objave publikacije2008-04-15
URL dokumentahttps://hrcak.srce.hr/23438
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-02-27 10:23:30