Reactions with 1-benzotriazolecarboxylic acid chloride. VIII. Synthesis of N-hydroxyisocyanate derivatives

Ostalo - Prikaz, pregled, osvrt

• Autor: Ivan Butula; MBZ: 6372
• Autor: Milena Jadrijević-Mladar Takač
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku kemiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

1,3,5-Trihydroxy-1,3,5-triazine-2,4,6(1<i>H</i>,3<i>H</i>,5<i>H</i>)-trione (<b>5</b>), the trimer of hypothetical acid HO-N=C=O, was synthesized by hydrogenolysis of 1,3,5-tribenzyloxy-1,3,5-triazine-2,4,6(1<i>H</i>,3<i>H</i>,5<i>H</i>)-trione (<b>4</b>). Similarly, the 1-(<i>N</i>-hiydroxycarbamoyl)benzotriazole (<b>6</b>), as »solid HONCO donor«, was prepared by hydrogenolysis of its benzyl derivatives <b>2</b>. Compound <b>4</b> was obtained by trimerization of intermediary <i>N</i>-benzyloxyisocyanate (<b>3</b>), which liberates in the thermal dis-sociation of 1-(<i>N</i>-benzyloxycarbamoyl)benzotriazole (<b>2</b>). In the reaction with 2-phenylethylamine, compound <b>6</b> gave <i>N</i>-hydroxy-<i>N</i>'-(2-phenylethyl)urea (<b>7</b>).

• Ključne riječi (engleski): 1-benzotriazolecarboxylic acid chloride; N-hydroxyisocyanate; 1,3,5-trihydroxy-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; 1-(N-hydroxy-carbamoyl)benzotriazole; 1-(N-benzyloxycarbamoyl)benzotriazole
• Jezik: engleski
• Vrsta publikacije: Ostalo - Prikaz, pregled, osvrt
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Croatica Chemica Acta
• Brojčani podaci: vol. 73, br. 2, str. 569-574
• p-ISSN: 0011-1643
• e-ISSN: 1334-417X
• URN:NBN: urn:nbn:hr:163:056918
• Datum objave publikacije: 2000
• URL dokumenta: https://hrcak.srce.hr/132071
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2020-04-29 11:15:38