Humani serumski albumin - najvažniji transportni protein u krvi

Stručni rad - Stručni rad

• Autor: Hrvoje Rimac
• Autor: Mirza Bojić
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku kemiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Human serum albumin (HSA) is the most abundant protein in human serum.
It bas numerous functions, one of which is transport of small hydrophobic molecules,
such as metabolites, hormones, and nutrients, as well as drugs and toxins. This promiscuous,
nonspecific affinity can !cad to competition and displacement of different
ligand in binding to HSA and cause increase in toxicity of displaced ligands. In this
paper, the most important HSA binding sites are described and the risk of displacement
interactions between different ligands is discused. W hile such interactions are
more common between physiological (e.g. fatty acids, bilirubin, heme etc) and patophysiological
ligands (e.g. indoxyl sulfate, indol-3-acetate, hypuric acid, and CMPF)
and drugs, displacement interactions between drugs are also known. In certain cases
these interactions can direct!y influence drug's free, active concentration in blood.

• Ključne riječi (hrvatski): humani serumski albumin; HSA
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Stručni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 73, br. 11, str. 793-808
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:432994
• Datum objave publikacije: 2017
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2020-06-19 10:39:31