Etilenglikol i dietilenglikol u zubnim pastama na hrvatskom tržištu

Znanstveni rad - Izvorni znanstveni rad

• Autor: Ivona Vidić Štrac
• Autor: Irena Žuntar
• Autor: Nino Dimitrov
• Autor: Maja Puklek
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku kemiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Diethylene glycol (DEG) (CAS 111-46-6) is a highly
toxic organic solvent that may cause nausea, dizziness, kidney failure, breathing
problems, convulsions and even coma when ingested The potential health
risks from chronic exposure to DEG are a particular concern in specific
vulnerable populations such as children and consumers with kidney or liver
disease. DEG is forbidden as cosmetic ingredient but can be present as an
impurity in glycerol and polyethylene glycols, common ingredients in oral
care products. Maximum permitted concentration as impurity is 0.1 % m/m.
the objective of this study was to determine the presence of diethylene glycol
in toothpaste on the Croatian market using a gas chromatography-mass
spectrometry method. Linearity of the response of mass detector was tested by
analyzing standard solutions with increasing concentrations of ethylene glycol
(EG) and diethylene glycol. Regression analysis of chromatographic data
indicates that linearity of response in the detector was within the examined
concentration area 0.5-50 mg/L, with correlation coefficients >0.998. Limit
of detection (LOD) far DEG was < 6 mg/kg, and far EG < 4 mg/kg. Testing
was conducted on 30 samples of toothpaste produced and marketed in Croatia
and EU. Obtained results were significantly below the permitted threshold
of 0.1 % thus assuring consumer safety.

• Ključne riječi (hrvatski): etilenglikol; dietilenglikol; zubne paste; otrovanje
• Jezik: hrvatski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 69, br. 5, str. 319-331
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:834051
• Datum objave publikacije: 2013
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2020-07-07 13:34:33