Najnovije spoznaje u istraživanju inhibitora aromataze

Stručni rad - Pregledni rad

• Autor: Mirza Bojić
• Autor: Marica Medić-Šarić
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku kemiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Most of the therapeutics used in chemotherapy are non selective drugs that act non
specifically, effecting healthy tissue and causing serious side effects (depression of bone
marrow, nausea, hair loss etc.). Every day new macromolecular targets are discovered.
One of very important targets in therapy of breast cancer is aromatase - CYP enzyme
unique for its function of converting male into female hormones. This paper is focused
to the enzyme and its mechanism of action, as this was explained very recently. Physiology
and patophysiology of aromatase is explained, as the basis for understanding action
of aromatase inhibitors. Special attention is devoted to expression of aromatase and
potential use of selective modulators of aromatase, as well as new indications of aromatase
inhibitors.

• Ključne riječi (hrvatski): aromataza; inhibitori aromataze; rak dojke
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 65, br. 10, str. 557-565
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:316740
• Datum objave publikacije: 2009
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2020-10-01 09:39:38