Mogu li biljni pripravci propolisa i ginkga smanjiti hiperreaktivnost trombocita u bolesti COVID-19?

Znanstveni rad - Izvorni znanstveni rad

• Autor: Andrea Antolić
• Autor: Željan Maleš
• Autor: Petra Galović
• Autor: Maja Tomičić
• Autor: Mirza Bojić
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku botaniku)
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku kemiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Propolis is flavonoid rich source that has shown numerous beneficial
biological effects such as antibacterial, antiviral, antitumoral,
antiaggregatory, and hepatoprotective. Ginkgo has been used as a dietary supplement
for enhancement of cognitive functions. The aim of this study was assessment
of the effect of propolis and ginkgo extracts on primary hemostasis and verify
whether the use of a combination of propolis and ginkgo extracts in the prevention
of cardiovascular diseases is justified. Commercially available extracts were assessed
by impedance aggregometry on the whole blood samples of healthy subjects collected
at the Croatian Institute of Transfusion Medicine. Two aggregation inducers were
used: ADP (adenosine diphosphate, weak agonist of platelet aggregation) and TRAP
(hexapeptide surrogate of thrombin, strong inducer of platelet aggregation). In an ADP induced aggregation assay, propolis showed an antiaggregatory effect at a
concentration of 10 μM. In the same test, the antiplatelet effect of ginkgo extract
was absent. In the hexapeptide-induced thrombin mimetic (TRAP) aggregation
test, propolis showed an antiplatelet effect at a concentration of 20 μM as well as
ginkgo extract. Combinations of propolis and ginkgo in a ratio of 1:25 and 1:50
showed an antiplatelet effect at 20 μM concentrations of extracts. Combination of
propolis and ginkgo is justified from a pharmacodynamic aspect, as propolis and
ginkgo have different mechanisms of action because they act on different signaling
pathways of aggregation.

• Ključne riječi (hrvatski): ginkgo; Ginkgo biloba L.; propolis; kardiovaskularne bolesti; agregacija trombocita; primarna hemostaza; COVID-19
• Jezik: hrvatski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 77, br. 3-4, str. 125-134
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:754620
• Datum objave publikacije: 2021
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-04-26 09:38:03