Primjena klorokina i hidroksiklorokina u suvremenoj terapiji

Stručni rad - Pregledni rad

• Autor: Branka Zorc
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku kemiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Chloroquine and hydroxychloroquine are 4-aminoquinoline
derivatives used for treatment of malaria for a very long period
and drugs of choice for the present time as well. Although they are on the World
Health Organization's List of Essential Medicines for many years, their mode of
action is a still a matter of debate. Various theories have been proposed and the
most accepted is that they interact with the parasite's ability to digest haemoglobin.
Chloroquine and hydroxychloroquine prevent hemozoin crystallization in
digestive vacuoles, bind to heme and form a highly toxic complex, which disrupts
membrane function.
Chloroquine and hydroxychloroquine are also disease-modifying antirheumatic
drugs, introduced empirically for the treatment of several autoimmune
diseases: rheumatoid arthritis, systemic lupus erythematosus, porphyria
cutanea tarda, primary Sjogren syndrome, Lyme arthritis and
antiphospholipid syndrome. With their immunomodulatory capacity they
prevent disease flares and promote long-term survival. In addition, both drugs
exert in vitro antiviral effects against a wide range of RNA-viruses. During
COVID-19 pandemia, they were used in clinical trials and emergency use programs
for the experimental treatment of this viral disease. Finally, numerous
studies have identified antitumor activities of chloroquine, hydroxychloroquine
and other antimalarial drugs.

• Ključne riječi (hrvatski): klorokin; hidroksiklorokin
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 77, br. 9-10, str. 465-478
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:393170
• Datum objave publikacije: 2021
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-12-15 15:34:17