prikaz prve stranice dokumenta Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface
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Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface
International Journal of Pharmaceutics, 633 (2023); 122622. https://doi.org/10.1016/j.ijpharm.2023.122622
Jurišić Dukovski, Bisera; Ljubica, Josip; Kocbek, P; Safundžić Kučuk, Maša; Krtalić, Iva; Hafner, Anita; Pepić, Ivan; Lovrić, Jasmina

Citirajte ovaj rad

Jurišić Dukovski, B., Ljubica, J., Kocbek, P., Safundžić Kučuk, M., Krtalić, I., Hafner, A. ... Lovrić, J. (2023). Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface. International Journal of Pharmaceutics, 633.. doi: 10.1016/j.ijpharm.2023.122622

Jurišić Dukovski, Bisera, et al. "Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface." International Journal of Pharmaceutics, vol. 633, 2023. https://doi.org/10.1016/j.ijpharm.2023.122622

Jurišić Dukovski, Bisera, Josip Ljubica, P Kocbek, Maša Safundžić Kučuk, Iva Krtalić, Anita Hafner, Ivan Pepić i Jasmina Lovrić. "Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface." International Journal of Pharmaceutics 633 (2023). https://doi.org/10.1016/j.ijpharm.2023.122622

Jurišić Dukovski, B., et al. (2023) 'Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface', International Journal of Pharmaceutics, 633. doi: 10.1016/j.ijpharm.2023.122622

Jurišić Dukovski B, Ljubica J, Kocbek P, Safundžić Kučuk M, Krtalić I, Hafner A, i sur.. Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface. International Journal of Pharmaceutics [Internet]. 18.01.2023. [pristupljeno 15.01.2025.];633. doi: 10.1016/j.ijpharm.2023.122622

B. Jurišić Dukovski, et al., "Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface", International Journal of Pharmaceutics, vol. 633, Siječanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:579310. [Citirano: 15.01.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:163:579310
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Podaci o radu
Naslov (engleski)Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface
AutorBisera Jurišić Dukovski
MBZ: 358592
AutorJosip Ljubica
AutorP Kocbek
AutorMaša Safundžić Kučuk
AutorIva Krtalić
AutorAnita Hafner
AutorIvan Pepić
AutorJasmina Lovrić
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za farmaceutsku tehnologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
Sažetak (engleski)
Ophthalmic oil-in-water nanoemulsions (NEs) are a complex technological platform, representing an advancement in the treatment of dry eye disease. In addition to enabling the incorporation of poorly soluble active pharmaceutical ingredients (APIs), NEs provide prolonged residence time of APIs and other formulation components and consequent replenishment and stabilization of the compromised tear film. Ophthalmic NEs have been on the market for over 20 years, but considering their complexity, as well as the complex nature of the ocular surface, they are still a poorly understood advanced dosage form. The objective of this study was to develop a biorelevant in vitro method that would be able to predict the behavior of ophthalmic NEs after application. With that goal, NE formulations differing in critical material attributes and critical formulation variables were employed and subjected to simulated tear turnover and blinking. By gradually increasing the complexity of the in vitro method, we were able to detect key parameters influencing NE stability. The undertaken study presents a step forward in the development of in vitro tools that are fundamental to the reliable, cost and time-effective development of innovative and generic topical ophthalmic NEs.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Pharmaceutics
Brojčani podacivol. 633, 122622
BPC4650 USD
p-ISSN0378-5173
e-ISSN1873-3476
DOIhttps://doi.org/10.1016/j.ijpharm.2023.122622
URN:NBNurn:nbn:hr:163:579310
Datum objave elektroničkog izdanja2023-01-18
ProjektŠifra: IP-2019-04-2174
Naziv (hrvatski): Nanoemulzije unaprijeđene biofarmaceutske vrijednosti za liječenje bolesti suhoga oka
Kratica: BeatDED
Voditelj: prof. dr. sc. Jasmina Lovrić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
URL dokumentahttps://www.sciencedirect.com/science/article/pii/S037851732300042X?via%3Dihub
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-01-14 11:46:36