Recreational scuba diving: negative or positive effects of oxidative and cardiovascular stress?

Znanstveni rad - Pregledni rad

• Autor: Antonija Perović
• Autor: Adriana Unić
• Autor: Jerka Dumić
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za biokemiju i molekularnu biologiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Medicinska biokemija

Sažetak (engleski)

Environmental conditions and increased physical activity during scuba diving are followed by increased production of free radicals and disturbed redox balance. Redox balance disorder is associated with damage of cellular components, changes of cellular signaling pathways and alterations of gene expression. Oxidative stress leads to increased expression of sirtuins (SIRTs), molecules which play an important role in the antioxidant defense, due to their sensitivity to the changes in the redox status and their ability to regulate redox homeostasis. These facts make SIRTs interesting to be considered as molecules affected by scuba diving and in that sense, as potential biomarkers of oxidative status or possible drug targets in reduction of reactive oxygen species (ROS) accumulation. In addition, SIRTs effects through currently known targets make them intriguing molecules which can act positively on health in general and whose expression can be induced by scuba diving.
A demanding physical activity, as well as other circumstances present in scuba diving, has the greatest load on the cardiovascular function (CV). The mechanisms of CV response during scuba diving are still unclear, but diving-induced oxidative stress and the increase in SIRTs expression could be an important factor in CV adaptation. This review summarizes current knowledge on scuba diving-induced oxidative and CV stress and describes the important roles of SIRTs in the (patho)physiological processes caused by the redox balance disorder.

• Ključne riječi (engleski): diving; oxidative stress; sirtuins; cardiovascular system
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Biochemia Medica
• Brojčani podaci: vol. 24, br. 2, str. 235-247
• p-ISSN: 1330-0962
• e-ISSN: 1846-7482
• DOI: https://doi.org/10.11613/BM.2014.026
• URN:NBN: urn:nbn:hr:163:591675
• Datum objave publikacije: 2014-06-15
• URL dokumenta: http://hrcak.srce.hr/125429
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2017-06-14 14:01:12