Analiza pripravaka sikavice tankoslojnom kromatografijom (Silybum marianum (L.) Gaertn.)

Scientific paper - Original scientific paper

• Author: Dubravka Tučkar
• Author: Mirjana Vrsalović
• Author: Danica Kuštrak
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

The milk thistle, Silybum marianum (L.) Gaertn. (= Carduus marianus
L.) belong to the Asteraceae family. The plant is of widespread distribution in the
Mediterranean area. It's fruits, Fructus Cardui Mariae, commonly known as seeds,
were traditionally employed as herbal remedy, while nowadays they or their preparations
in effective dosage are recognized as a modem phytomedicine. Wagner et al. (1968)
found in fruits of the milk thistle a group of compounds named silymarin. Further
studies showed that silymarin consists of four compounds: silibinin, isosilibinin, silicristin
and silidianin. The term flavonolignans has been proposed for molecules of this
structure.
Indications for silymarin therapeutic use are: toxic liver damage, supportive treatment
in chronic inflammatory liver diseases and cirrhosis.
-The aim of this research was to check up the presence of silymarin components in the
plants cultivated in Croatia (in the open air). Thin-layer chromatography (TLC) was
used for qualitatiue analysis of flauonolignans. The analysis showed the presence of
silibinin, silicristin and silidianin with silibinin as the main component (ca. 50%) in
the extracts of fruit. Components detected in the leaf extract seem to belong to flavonoid
derivatives.

• Keywords (croatian): tankoslojna kromatografija; sikavica; Silybum marianum (L.) Gaertn.; silimarin
• Language: croatian
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 59, no. 7-8, pp. 303-310
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:741319
• Publication: 2003
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-02-17 13:00:33