Analiza pripravaka sikavice tankoslojnom kromatografijom (Silybum marianum (L.) Gaertn.)

Znanstveni rad - Izvorni znanstveni rad

• Autor: Dubravka Tučkar
• Autor: Mirjana Vrsalović
• Autor: Danica Kuštrak
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmakognoziju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

The milk thistle, Silybum marianum (L.) Gaertn. (= Carduus marianus
L.) belong to the Asteraceae family. The plant is of widespread distribution in the
Mediterranean area. It's fruits, Fructus Cardui Mariae, commonly known as seeds,
were traditionally employed as herbal remedy, while nowadays they or their preparations
in effective dosage are recognized as a modem phytomedicine. Wagner et al. (1968)
found in fruits of the milk thistle a group of compounds named silymarin. Further
studies showed that silymarin consists of four compounds: silibinin, isosilibinin, silicristin
and silidianin. The term flavonolignans has been proposed for molecules of this
structure.
Indications for silymarin therapeutic use are: toxic liver damage, supportive treatment
in chronic inflammatory liver diseases and cirrhosis.
-The aim of this research was to check up the presence of silymarin components in the
plants cultivated in Croatia (in the open air). Thin-layer chromatography (TLC) was
used for qualitatiue analysis of flauonolignans. The analysis showed the presence of
silibinin, silicristin and silidianin with silibinin as the main component (ca. 50%) in
the extracts of fruit. Components detected in the leaf extract seem to belong to flavonoid
derivatives.

• Ključne riječi (hrvatski): tankoslojna kromatografija; sikavica; Silybum marianum (L.) Gaertn.; silimarin
• Jezik: hrvatski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 59, br. 7-8, str. 303-310
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:741319
• Datum objave publikacije: 2003
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-02-17 13:00:33