Eikozanoidi i njihovo djelovanje na pojedine organske sustave

Stručni rad - Pregledni rad

• Autor: Petra Turčić
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmakologiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Eicosanoids are arach.idonic acid derivatives that play a significant role in th.e physiology
and pathophysiology of the human body. Ph.ospholipases present in various cell
types are involved in the release of arachidonic acid th.at can be metabolized by
cyclooxygenases that results information of prostaglandins, prostacyclines and thromboxanes
or by lipooxygenase with the formation of leukotrienes and hydroxyeicosatetraenoic
acids (HETEs); or cytochrome P450 with the formation of epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs). The metabolism as well as the
physiologic and pathophysiologic action of eicosanoids is described. Various drugs interfere
with the production and degradation of eicosanoids modifying their effects on the
body. Better understanding of eicosanoid bioactivity could help in the research and identification
of novel pharmaceutical forms suitable for the treatment of diseases such as
autoimmune diseases, inflammation, glomerulonephritis, malignancies, Alzheimer's
disease, etc.

• Ključne riječi (hrvatski): eikozanoidi; prostaglandini; leukotrieni
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 64, br. 11, str. 593-604
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:741100
• Datum objave publikacije: 2008
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2020-09-28 09:22:38