Krkavina (Frangula alnus Mili.) - botanički podaci, fitokemijski sastav i biološki učinci

Stručni rad - Pregledni rad

• Autor: Matija Salopek
• Autor: Ivan Sušanj
• Autor: Maja Bival Štefan
• Autor: Jasna Jablan
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za analitičku kemiju)
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmakognoziju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Laxative property of dried bark of Frangula alnus Mill. (synonym Rhamnus frangula
L.) is known for centuries and it is still in use in treatment of constipation.
Medicines based on F. alnus bark (Frangulae cortex) according to the EU parliament
and European medicines agency products for human use are considered as medicinal
products with »well-established medicinal use«. Nowadays on Croatian's market are
available F. alnus-based preparations in the form of tea, pills or powders. Laxative
property of F. alnus bark is attributed to its main constituents, anthraquinones, anthracene
derivatives which are class of the pharmacologically active natural compounds.
The main anthraquinone present in the bark of F. alnus is emodin and laxative property
of F. alnus bark is directly connected to emodin. However, recent studies have
shown that biological effects of F. alnus bark and its main antraquinone emodin are
much broader than just a laxative effect. lt is shown that they have antimicrobial,
antiviral, antifungal and antioxidant effect. Furthermore, for emodin is shown antitumour
effect. Except to their positive biological effects, it is demonstrated that bark
of F. alnus and emodin are toxic. Therefore, treatment of constipation with medicines
based on bark of F. alnus should only be considered for short term use.

• Ključne riječi (hrvatski): krkavina; Frangula alnus Mill. Bark; opstipacija; laksativ; kora krkavine; emodin
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 72, br. 10, str. 651-670
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:044070
• Datum objave publikacije: 2016
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2020-09-29 09:48:00