Psihotropna biljna vrsta Salvia divinorum Epl. & Jativa - izvor najpotentnijeg halucinogena u prirodi

Stručni rad - Pregledni rad

• Autor: Darija Šarić
• Autor: Zdenka Kalođera
• Autor: Zdravko Lacković
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmakognoziju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (hrvatski)

This review article summarizes the current knowledge about the metabolism, pharmacological
effect, traditional and modem therapeutic use and safety of S. divinorum.
Salvia divinorum is a plant of the Lamiaceae family which has a psychoactive, hallucinogenic
effect. The main psychoactive ingredient is diterpene salvinorin A which is considered
the most potent natural hallucinogen. Hallucinogenic doses in humans are estimated
as low as 200-500 μg. ln the traditional medicine the plant is consumed
primarily to encourage shamanic visions in the context of healing or divination, but also
as a drug at lower doses (diuretic, antidiaroic, antianemic, analgesic and antirheumatic).
The research has shown that salvinorin A is a potent K-opioid receptor agonist. K-opioid
receptors agonists are of therapeutic importance in treating pain and possibly drug
addiction, eating disorders, depression, and even in the treatment of human immunodeficiency
virus (HIV). However, salvinorin A represents a new class of selective K-opioid
receptor agonist without nitrogen in its structure. Such agonists have profound influence
on human cognition and perception. There are suggestions that salvinorin A could
be useful in treating certain psychiatric disorders (eg Alzheimer's disease, schizophrenia,
bipolar disorder and dementia). lt also becomes a new molecular candidate in the development
of antipsychotic drugs.

• Ključne riječi (hrvatski): rod Salvia; Salvia divinorum; meksička kadulja; psihoaktivne biljke; prirodni halucinogeni; salvinorin A
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 66, br. 10, str. 523-541
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:495946
• Datum objave publikacije: 2010
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2020-10-02 13:06:01