Lipofilnost lijekova. III. dio: Fragmentarni sustav Hanscha i Leoa

Stručni rad - Stručni rad

• Autor: Marica Medić-Šarić
• Autor: Danijela Franić
• Autor: Željko Debeljak
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku kemiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Lipophilicity is a property of molecular structure which is essential in
predicting the transport and activity of drugs, pesticides and various xenobiotics.
The most important parameter which describes lipophilicity in a numerical
way is partition coefficient P. It describes the manner in which a
bioactive solute partitions between polar and nonpolar phases. For that reason,
beside experimental methods for it's determination, there are developed
numerical approaches for it's calculation. The most common methods are: by
substituting groups for hydrogen (II system) and by summing the appropriate
structural elements (fragment systems). In log P calculations today more
often are in use computer programs based on this methods.
Log P is a widely used parameter in QSAR for quantitative description
of lipophilic character of biologically active compounds. Molecular modeling
in pharmacy and chemistry is used to rationalize drug design process in order
to predict properties and activity, and to reduce the number of compounds
to be synthesized.

• Ključne riječi (hrvatski): lipofilnost lijekova; QSPR; QSAR
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Stručni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 54, br. 4, str. 113-131
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:907594
• Datum objave publikacije: 1998
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-03-05 11:01:28