Terapijski sustavi kontroliranog oslobađanja u debelom crijevu

Stručni rad - Pregledni rad

• Autor: Željka Pavelić
• Autor: Biljana Nigović
• Autor: Petra Konosić
• Autor: Mira Bećirević-Laćan
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za analitiku i kontrolu lijekova)
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku tehnologiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Colon-specific drug delivery systems offer several potential therapeutic advantages. In
a number of colonic diseases such as colorectal cancer, Crohn's disease and spastic
colon, it has been shown that local is more effective than systemic delivery. Colonic drug
delivery can be achieved by oral or by rectal administration. Rectal delivery forms
(suppositories and enemas) are not always effective because a high variability is observed
in the distribution of drugs administered by this route. Therefore, oral route is preferred.
Absorption and degradation of the active ingredient in the upper part of the gastrointestinal
tract (GIT) is the major obstacle with the delivery of drugs by oral route and
must be overcome for successful colonic drug delivery.
Drugs for which the colon is a potential absorption site (e.g. peptides and proteins)
can be delivered to this region for subsequent systemic absorption. The digestive enzymes
of the GIT generally degrade these agents. However, these enzymes are present in
significantly lower amounts in the colon compared with the upper portion of the GIT.
Colon-specific drug delivery has been attempted in a number of ways that primarily
seek to exploit the changes in the physiological parameters along the GIT. These approaches
include the use of prodrugs, pH-sensitive polymers, bacterial degradable polymers,
hydrogels and matrices, as well as multicoating time-dependent delivery systems.
The use of these strategies to target drug delivery to the colon is addressed in detail.

• Ključne riječi (hrvatski): debelo crijevo; kontrolirano oslobađanje lijeka; apsorpcija lijeka; enzimatski kontrolirani terapijski sustavi; vremenom kontrolirani terapijski sustavi
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 62, br. 9, str. 455-469
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:115350
• Datum objave publikacije: 2006
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-02-18 14:42:25